معرفی
Poul Nielsen is a Professor in the Department of Physics, Chemistry and Pharmacy at the University of Southern Denmark (SDU), where he also serves as Associate Dean for Education in the Faculty of Science. He leads a research group at the Nucleic Acid Center, focusing on nucleic acid chemistry and medicinal chemistry. His academic affiliations are deeply rooted in SDU, where he has advanced from lecturer to full professor and academic leadership.
- Cand. Scient. in Chemistry and Biology, Odense University, 1994
- Ph.D. in Organic Chemistry, Odense University, 1998
- Adjunct, Chemical Institute, SDU, 1998–2001
- Lecturer, Chemical Institute, SDU, 2001–2008
- Professor, Institute for Physics and Chemistry, SDU, from July 2008
- Associate Dean for Education, Faculty of Science, from January 2018
Poul Nielsen's research centers on nucleic acid chemistry, medicinal chemistry, and synthetic organic chemistry. His work spans the design and synthesis of modified nucleosides and oligonucleotides, with applications in drug development, diagnostics, and synthetic biology. Key areas include G-quadruplex stabilization, double-headed nucleotides, and antibiotic development using pleuromutilin scaffolds. His fingerprint highlights expertise in oligonucleotides, monomers, DNA, nucleosides, and nucleic acid bases.
His recent publications (2023–2025) reflect a strong trend in medicinal chemistry and pharmaceutical sciences, particularly in antibiotic discovery (e.g., triaromatic pleuromutilins targeting MRSA) and drug delivery (e.g., bioavailability enhancement via co-formulation). He also contributes to chemical biology with fluorescent probes for membrane and DNA analysis. These works demonstrate interdisciplinary collaboration, combining synthetic chemistry with biophysics and pharmacology.
Poul Nielsen is actively involved in research funding and academic service. He participates in multiple projects funded by Novo Nordisk Fonden, Carlsbergfondet, and Hørslev Fonden, focusing on antibiotic development and nucleotide purification. He supervises postdoctoral researchers and students, engages in peer review, and serves on examination committees at other Danish universities. His public engagement includes media contributions on education and AI in academia.
He leads the Poul Nielsen's Group at SDU’s Nucleic Acid Center, which conducts cutting-edge research in nucleotide chemistry. The group collaborates nationally and internationally, with ties to institutions like the University of Liverpool and The Scripps Research Institute. They are involved in both fundamental and applied research, aiming to translate chemical innovations into biomedical applications.
