Pietro Genovese

Pietro Genovese is an Assistant Professor of Pediatrics at Boston Children's Hospital, specializing in gene editing and hematopoietic stem cell research. His work focuses on developing therapeutic strategies for genetic disorders, immunodeficiencies, and cancer through advancements in CRISPR/Cas9 and base editing technologies. Genovese leads the Genovese Lab, investigating topics such as hematopoietic stem cell function preservation, clonal tracking, and targeted immunotherapies for acute myeloid leukemia and SCID-X1.

Research Interests: Gene Editing in Stem Cells, Hematological Disorders, Immune Engineering, Oncology, and Genetic Disease Correction. His lab's innovations include enhancing gene editing efficiency while minimizing DNA damage responses, as well as optimizing viral vector production for therapeutic applications. Genovese collaborates extensively with institutions like Harvard Medical School and co-authors frequently on topics like CAR-T cell reprogramming and mesenchymal stromal cell support in transplants.

Publications highlight breakthroughs in areas such as CX3CR1 haploinsufficiency effects in transplant recipients, IL-12-modified NK T cells for tumor targeting, and epitope editing for leukemia treatment. His work bridges basic science with clinical translation, aiming to cure genetic blood disorders and advance cellular therapies.

Labs/Teams: Genovese Lab (active on Twitter @Genovese_Lab). Collaborations include global teams in gene therapy development and stem cell biology.