Isabelle André

Isabelle André is a Researcher and Laboratory Director at INSERM, leading the Human Lymphohematopoiesis laboratory at the Imagine Institute. Her work focuses on understanding human hematopoietic immune system development and advancing cell and gene therapies for inherited/acquired blood disorders. Key areas of research include hematopoietic stem cell transplantation, T-cell generation, and artificial thymus engineering to reduce immune deficiency post-transplantation.

Research Interests: Her studies explore mechanisms underlying T and B cell differentiation, gene therapy applications, and identifying novel genes causing immune deficiencies. Notable contributions include demonstrating AZT's genotoxic effects during pregnancy and developing protocols for ex vivo gene-modified stem cell therapies.

Publications Trends: Recent work emphasizes genetic profiling in cancer, CAR-T cell therapy optimization, and clonal dynamics in gene therapy patients. Her team also investigates immune reconstitution strategies using engineered T-lymphoid progenitors.

Grants & Patents: Awarded multiple national/European grants; holds patents related to gene therapy and stem cell mobilization. Collaborates on clinical trials for SCID and other immune deficiencies.

Lab Team: The team includes researchers, engineers, and clinicians (e.g., Marina Cavazzana, Sven Kracker), supporting translational research from basic science to clinical applications.