معرفی
Pierre Paoletti is a Professor at the Département de Biologie of the École Normale Supérieure, leading the research team Récepteurs du Glutamate et Synapses Excitatrices. His work focuses on the molecular mechanisms of excitatory synapses, particularly NMDA receptors' role in synaptic plasticity and neurodevelopmental/neuropsychiatric disorders. His multi-disciplinary approach integrates molecular neuroscience, protein engineering, optogenetics, and computational biology to understand neuronal communication and design precision therapies.
Key research areas include NMDA receptor structure-function relationships, synaptic zinc dynamics, optogenetic control of receptors, and the therapeutic potential of receptor modulation. His team has published in top journals such as Nature Neuroscience, Neuron, and Science.
Major contributions include uncovering GluN3A receptor signaling in cortical circuits, GABA binding to GluD1 receptors, and allosteric modulation mechanisms of NMDA receptors. Collaborations span neuroimaging, behavior studies, and translational research in epilepsy and schizophrenia.
