Pierre Palamini

Pierre Palamini is a researcher at the Laboratory of Catalysis and Organic Synthesis within the Institute of Chemical Sciences and Engineering at École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland. His work focuses on developing novel synthetic methodologies in organic chemistry.

His research interests center on organic synthesis with particular emphasis on photocatalysis, radical chemistry, and azide chemistry. Palamini specializes in alkene functionalization techniques and synthetic methodology development, with applications in pharmaceutical intermediate synthesis. His work often involves radical-polar crossover strategies and the use of hypervalent iodine reagents to achieve regioselective transformations of various alkene substrates including vinyl arenes, enamides, enol ethers, and vinyl sulfides.

Analysis of his publications reveals a strong focus on developing efficient synthetic routes for pharmaceutical intermediates through azidofunctionalization chemistry. His research employs photoredox conditions and demonstrates broad substrate scope across multiple alkene and nucleophile combinations. The work shows significant improvements in synthetic efficiency compared to previous approaches, with reductions in step count and increases in overall yield.

Palamini collaborates closely with Prof. Jerome Waser's research group at EPFL, working within the Laboratory of Catalysis and Organic Synthesis. His research methodology incorporates computational approaches for substrate selection, using clustering techniques to systematically evaluate reaction scope across thousands of potential combinations.