معرفی
Prof. Dr. Petr Chlanda is a W3-Heisenberg Professor at the University of Heidelberg's Department of Virology, part of the Center for Infectious Diseases. He leads the Chlanda Lab, focusing on cryo-electron microscopy (cryo-EM) to study viral-membrane interactions during infection. His work involves advanced techniques like cryo-FIB milling, cryo-ET, and correlative light-electron microscopy.
Research projects include influenza A virus entry mechanisms, SARS-CoV-2 replication organelles, and Ebola virus assembly. He collaborates with institutions like the Luxembourg Institute of Science and Technology to explore lipid distributions in infected cells using cryo-SIMS. His lab has pioneered methods like dual-axis Volta phase plate cryo-ET and cryo-CLEM workflows for adherent cells.
Key achievements include identifying SARS-CoV-2 nsp3/nsp4 pore constituents and demonstrating IFITM3's role in blocking viral entry via lipid sorting. His work is funded by the SFB1129 and supported by the DFG Heisenberg Programme. The lab has produced over 20 publications since 2020, with recent breakthroughs in Ebola viral factory maturation and SARS-CoV-2 membrane structure characterization.
Prof. Chlanda advises over 15 graduate students, including current PhD candidates and postdocs like Liv Zimmermann and Moritz Wachsmuth-Melm. His team operates from BioQuant facilities in Heidelberg, collaborating internationally on projects funded by Horizon EU and the Chica and Heinz Schaller Foundation.
