Peter M. Tessier

Peter M. Tessier is the Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering at the University of Michigan. He leads the Tessier Lab, focusing on developing advanced therapeutic antibodies to address critical biomedical challenges, particularly in central nervous system disorders and cancer therapy.

• Departments: Pharmaceutical Sciences, Chemical Engineering
• Location: B10-A179 NCRC, 2800 Plymouth Road, Ann Arbor, MI
• Contact: (734) 763-1486 | ptessier@umich.edu

Research Interests:

• Bispecific antibodies for brain delivery of biologics (e.g., antibodies, cytokines, gene silencing agents)
• Therapeutic applications for neurodegenerative disorders (Alzheimer's, Parkinson's), autoimmune diseases (Multiple Sclerosis), brain cancer, and traumatic brain injury
• Conformational antibodies for detection/treatment of neurodegenerative diseases
• Non-invasive gene expression modulation in the brain
• Antibody-drug conjugates for cancer therapy and gene silencing
• Agonist/bispecific antibodies activating T cells for cancer treatment

Technological Focus: Protein engineering, directed evolution, high-throughput screening, and computational methods integrating machine learning and AI.

Scientific Awards:

• Albert M. Mattocks Professorship

Laboratory Overview: The Tessier Lab logo symbolizes their interdisciplinary work, merging antibody engineering (represented by antibody structures) with computational approaches (network patterns). The DNA helix motif underscores their emphasis on gene expression modulation, while the brain/spinal cord imagery highlights their focus on central nervous system disorders.