Peter C. Amadio

Peter C. Amadio, M.D. is a Professor of Orthopedics and Professor of Biomedical Engineering at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. He holds the distinguished position of Lloyd A. and Barbara A. Amundson Professor of Orthopedics and serves as Principal Investigator of the Tendon and Soft Tissue Biology Laboratory. Dr. Amadio previously served as Dean for Research Academic Affairs (2012-2022) and is an active member of the Division of Hand Surgery in the Department of Orthopedic Surgery.

Dr. Amadio's educational background includes an MD from Jefferson Medical College, Thomas Jefferson University, and a BS from Pennsylvania State University. His clinical training encompassed a Hand Fellowship at Thomas Jefferson University, Chief Residency in Orthopaedics at Massachusetts General Hospital (Harvard Medical School), and an Orthopaedic Residency at Harvard Combined Orthopaedic Residency Program.

His research focuses on tendon biology and carpal tunnel syndrome, with particular emphasis on

• Tendon lubrication and adhesion prevention
• Ultrasound biomarkers for carpal tunnel syndrome
• Novel treatments including senolytic therapies for carpal tunnel syndrome
• Development of a comprehensive 3D atlas of hand anatomy

Dr. Amadio collaborates extensively with the Center for Regenerative Biotherapeutics and the Robert and Arlene Kogod Center on Aging at Mayo Clinic.

Analysis of Dr. Amadio's recent publications reveals a strong focus on translating basic science discoveries into clinical applications. His work spans biomechanics, tissue engineering, ultrasound imaging, and senolytic therapies, with an emphasis on developing non-surgical alternatives to traditional hand surgery procedures. The research demonstrates a progression from fundamental tendon biology toward clinical translation and commercialization.

Among his notable scientific achievements:

• Distinguished Mayo Investigator (2018)
• CORR ORS Richard A. Brand Award for Outstanding Orthopaedic Research (2014)
• Fellow, American Institute for Medical and Biological Engineering (2021)
• President, Orthopaedic Research Society (2021-2022)

Dr. Amadio has secured significant research funding including multiple NIH grants and Congressionally Directed Medical Research Programs funding. His laboratory has developed treatments that have already changed clinical practice in tendon surgery. Current projects include the FITCATS clinical trial investigating fisetin for carpal tunnel syndrome and development of a biological product to prevent tendon adhesions.

The Tendon and Soft Tissue Biology Laboratory, directed by Dr. Amadio, employs a multidisciplinary approach combining orthopedics, biomechanics, biochemistry, dynamic ultrasound, and molecular and cell biology to improve outcomes in tendon repair and carpal tunnel syndrome treatment.