معرفی
Paulo W. Pires is an Associate Professor at the University of Arizona, holding appointments in the Departments of Physiology, Physiological Sciences (GIDP), Surgery, Neurosurgery, and Neuroscience (GIDP). His research focuses on the role of brain vasculature in cognitive impairment and dementia, particularly Alzheimer’s Disease and aging-related mechanisms.
- BS, Biological Sciences (2004, Sao Paulo State University)
- MS, Cell Biology (2007, Campinas State University)
- PhD, Pharmacology and Toxicology (2013, Michigan State University)
- Postdoctoral Fellowship (2018, University of Nevada)
The Pires laboratory investigates how misfolded proteins like amyloid-beta impair ion channels in brain blood vessels, leading to reduced cerebral blood flow. Key areas include neuroinflammation, oxidative stress, potassium channel dysfunction, and cholesterol-mediated vascular impairment in aging and Alzheimer’s disease.
Current research trends explore neurovascular coupling disruption in menopause models, amyloid-beta-induced calcium signaling anomalies, and oxidative stress interactions with vascular potassium channels. These studies bridge vascular physiology, neurodegenerative disease mechanisms, and age-related cognitive decline.
Dr. Pires leads the Pires Laboratory at MRB 426, focusing on cerebral vascular dysfunction through interdisciplinary approaches integrating molecular biology, physiology, and neuroimaging techniques.
