Paul Yushkevich

Paul Yushkevich is a Professor in the Department of Radiology at the University of Pennsylvania and a member of the Bioengineering Graduate Group. His research focuses on computational methodologies for biomedical imaging data, particularly automatic segmentation and morphometry of the hippocampal formation in Alzheimer’s disease.

• Education: PhD in Computer Science from University of North Carolina Chapel Hill

His work bridges machine learning and neurodegenerative disease research, with recent publications emphasizing MRI analysis, tau pathology, and longitudinal biomarker studies in Alzheimer’s disease. Dr. Yushkevich develops tools for automated segmentation of brain structures and investigates the interplay between neurodegeneration, cerebral blood flow, and cognitive decline.

Current research trends include:

• High-resolution MRI segmentation of medial temporal lobe subregions
• Quantitative tau burden metrics (e.g., Tau-MaX)
• Neural correlates of preclinical Alzheimer’s
• Integration of plasma biomarkers with structural imaging
• Postmortem MRI-histology validation protocols

Dr. Yushkevich’s contributions span Alzheimer’s disease, dementia subtyping, and open-source medical image analysis tools.