Paul Wiseman

Paul Wiseman is a Professor of Chemistry and Physics at McGill University, holding the Otto Maass Chair in Chemistry. He earned a B.Sc. (Hons) in Chemistry from St. Francis Xavier University (1989) and a Ph.D. in Chemistry from the University of Western Ontario (1995). His research focuses on biophysical chemistry, particularly measuring macromolecular interactions in living cells using advanced microscopy techniques like image correlation spectroscopy (ICS) and image cross-correlation spectroscopy (ICCS). His work addresses cellular adhesion mechanisms, receptor dynamics, and the development of novel imaging methods such as third harmonic generation (THG) microscopy and quantum dot labeling.

Wiseman’s research group employs cutting-edge equipment, including light sheet, TIRF, multiphoton, and STED microscopes, to study protein transport, signaling, and membrane organization. His contributions have been recognized with awards like the Biophysical Society Young Fluorescence Investigator (2005), Leo Yaffe Award for Teaching (2007), and the Keith Laidler Award (2009). He currently advises PhD students in interdisciplinary fields spanning biophysics, cell biology, and microscopy.

His lab explores topics such as CFTR protein dynamics in cystic fibrosis, mechanosensing in immune cells, and the role of cholesterol in membrane receptor regulation. Collaborations with the NIH Cell Migration Consortium and editorial roles at Biointerfaces and Biophysical Journal highlight his leadership in the field. The Wiseman Group’s innovations in microscopy techniques enable unprecedented insights into cellular processes at the molecular level.