Paul Linsdell

Paul Linsdell is a Professor in the Department of Physiology and Biophysics at Dalhousie University's Faculty of Medicine. His research focuses on ion channel structure and function, particularly the CFTR chloride channel mutated in cystic fibrosis. He holds a BSc from University College London, a PhD from the University of Leicester, and postdoctoral training at the University of Washington and McGill University.

Research interests include understanding CFTR's detailed function through electrophysiological techniques, studying normal and mutant protein forms. Key techniques used: site-directed mutagenesis, mammalian cell transfection, and patch clamp electrophysiology.

Publications span 2017-2022, emphasizing anion binding, conductance mechanisms, and CFTR pore architecture. His work contributes to understanding cystic fibrosis pathophysiology at molecular level.

Dr. Linsdell's lab investigations aim to unravel ion channel dysfunction mechanisms, with potential implications for therapeutic developments in cystic fibrosis treatment.