Paul Klenerman

Paul Klenerman is a Professor at the Nuffield Department of Medicine within the Medical Sciences Division, University of Oxford. His research focuses on immune responses to infectious diseases including HIV, hepatitis B/C, and SARS-CoV-2, with emphasis on T-cell biology, vaccine development, and host-pathogen dynamics.

• Email: paul.klenerman@medawar.ox.ac.uk
• Collaborators: Ellie Barnes (Oxford), Adrian Hill (Oxford), Georg Lauer (Harvard), Robert Thimme (Freiburg), and others across 12 institutions.

Key research themes include: CD161++/MAIT cell biology (bacterial/viral defense, liver immunology), HCV immune defense (vaccine trials using adenoviral vectors), and memory inflation (persistent immune responses post-viral infections).

Recent publications (2024-2025) span vaccine immunology (hybrid immunity, bivalent boosters), liver immunobiology (MAIT cell repair mechanisms), infectious disease dynamics (HCV persistence, dengue progression), and single-cell analysis of gut/lung pathologies.