معرفی
Dr. Paul Guichard is an Associate Professor at the University of Geneva's Department of Molecular and Cellular Biology. His research focuses on deciphering the structural mechanisms governing centriole assembly through multidisciplinary approaches including cryo-electron tomography, expansion microscopy, and in vitro reconstitution assays.
- Current research projects: Centriole structure/function, Expansion Microscopy developments, Ciliopathy & Eye diseases, Immune Synapse Architecture, Molecular conoid studies, Plankton ultrastructural diversity
The lab's recent work (2020-2024) has revealed key insights into centriole cohesion, microtubule organization, and protein complexes critical for ciliogenesis. Their structural analyses of centriole components across species (Paramecium, Chlamydomonas, Trichonympha) highlight evolutionary conservation.
- Key techniques: Cryo-ET, U-ExM, in vitro assays, 3D reconstruction
- Funding: Fondation privée des HUG (Plasmodium conoid studies)
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