Patrick Gunning

Patrick Gunning is a Professor at the University of Toronto (Mississauga campus), specializing in Biological Chemistry and Organic Chemistry. His research focuses on developing small molecule architectures to manipulate protein complexation events, particularly targeting aberrant protein interactions in diseases like cancer. Key areas include STAT3/STAT5 inhibition, histone deacetylase (HDAC) modulation, and molecular design strategies for cancer therapies.

Research interests emphasize understanding protein-protein interaction 'hot spots' and designing drugs to suppress or enhance specific gene expressions. His work explores both organic and inorganic drug-like scaffolds to regulate cellular signaling pathways. Recent studies highlight novel treatments for leukemia, lymphoma, and brain metastases through targeted protein degradation and metabolic pathway manipulation.

Over 50 publications demonstrate expertise in oncology, epigenetics, and drug discovery. Notable contributions include HDAC6-selective inhibitors, PROTAC-based degraders, and fluorine NMR methodologies for protein analysis. His interdisciplinary approach bridges organic chemistry, biochemistry, and clinical applications in precision medicine.

Current projects investigate molecular mechanisms underlying cancer growth, with a focus on STAT signaling pathways and metabolic vulnerabilities. The lab also pioneers innovative drug delivery strategies using advanced spectroscopic techniques and chemical synthesis platforms.