Jeanne Stuckey

Jeanne Stuckey is a Research Professor at the Life Sciences Institute of the University of Michigan, specializing in Medicinal Chemistry and Cancer Biology. Her work focuses on the development of targeted protein degradation therapies and small-molecule inhibitors for oncological applications.

• Research Areas: Targeted Protein Degradation (STAT3/5/6, SMARCA2/4), RNA Splicing, Eukaryotic Translation, Mitochondrial Metabolism
• Key Collaborators: Shaomeng Wang, Jennifer Meagher, Chao-Yie Yang, Duxin Sun

Her publications demonstrate expertise in designing PROTAC degraders and prodrugs for cancer-related targets, including SMARCA2 (synthetic lethality in SMARCA4-deficient cancers), STAT3/5/6 (oncogenic transcription factors), and eIF4E (cap-dependent translation). She has contributed to advancements in BRD4 inhibitors and ST2 inhibitors for antitumor and anti-inflammatory applications.

Recent work includes the development of SMD-3236 (SMARCA2 degrader), SD-436 (STAT3 degrader), and AK-1690 (STAT6 degrader), highlighting her focus on precision oncology and molecular targeting. She also co-authored studies on SIRT5 variants and PKM2 activators for metabolic and neuroprotective applications.