Pascale V Guillot

Pascale V Guillot is a Professor of Stem Cell and Gene Therapy at University College London, based at the Zayed Centre for Research into Rare Diseases in Children (ZCR) within the Great Ormond Street Institute of Child Health. She specializes in Maternal & Fetal Medicine with a research focus on developing stem cell-based therapies for rare pediatric conditions, particularly osteogenesis imperfecta and neonatal brain injuries. Her work bridges laboratory research with potential clinical applications through innovative approaches using amniotic fluid stem cells and gene editing technologies.

Her research interests center on regenerative medicine approaches for rare childhood diseases. Guillot leads the Laboratory of Stem Cell and Exosome Therapy, which combines induced pluripotent stem cells and gene editing to design nanotherapeutics targeting skeletal disorders like osteogenesis imperfecta (brittle bone disease) and neurological conditions including neonatal encephalopathy and stroke. Her work demonstrates particular expertise in amniotic fluid stem cells, their differentiation potential, and therapeutic applications in both bone and brain disorders.

Analysis of her publication record reveals a consistent trajectory focused on translational stem cell research. Her most recent work (2024-2025) shows expansion into clinical applications of previously developed therapies, including real-world efficacy studies. Throughout her career, Guillot has maintained strong focus on amniotic fluid and fetal stem cells, with progressive refinement from basic characterization to therapeutic applications, particularly in skeletal and neurological disorders. Her research demonstrates significant interdisciplinary integration of cell biology, nanomedicine, and clinical pediatrics.

Guillot maintains active collaborations across multiple institutions as evidenced by her extensive co-authorship network. Her laboratory at the Zayed Centre utilizes advanced techniques including micro-computed tomography for bone analysis and sophisticated stem cell characterization methods. She has contributed significantly to understanding the therapeutic potential of various stem cell populations, particularly those derived from amniotic fluid and fetal tissues, with emphasis on their application in rare genetic disorders affecting children.