Paolo De Los Rios

Paolo De Los Rios is an Associate Professor at the École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the School of Basic Sciences (SB) and the Laboratoire de Biophysique Statistique (LBS). He holds multiple roles, including teaching responsibilities in the Physics department and doctoral program leadership in the Programme doctoral Physique. His research focuses on molecular chaperones, protein folding mechanisms, and statistical physics of biomacromolecules, with a particular emphasis on entropy-driven processes and nonequilibrium thermodynamics.

He has advised numerous PhD students, including Subhasis Dehury, Lisa Gennai, and María Li López Bautista, among others. His work bridges experimental and theoretical approaches, often utilizing single-molecule techniques and computational models to study protein dynamics. Notable contributions include elucidating the role of Hsp70 chaperones in protein disaggregation and understanding the thermodynamic principles governing cellular processes.

His research articles frequently explore topics such as chaperone machinery, nonequilibrium systems, and the interplay between thermodynamics and biological function. He has also contributed to interdisciplinary areas like sphingolipid metabolism and ABC transporter evolution. His academic service includes roles in doctoral commission governance and educational program development.