Paola Barbagallo

Paola Barbagallo serves as a Guest Researcher in the Department of Neuroscience within the Faculty of Health and Medical Sciences at the University of Copenhagen. Her work centers on elucidating synaptic mechanisms underlying neurological disorders through advanced neuronal modeling and molecular analysis.

Her primary research domains include Synaptic Transmission, Neurodegenerative Diseases, Epilepsy, and Neurogenetics, with emphasis on pathogenic variants in synaptic proteins like SNAP25 and STXBP1. She investigates how these mutations disrupt neuronal signaling and contribute to conditions such as encephalopathy and amyotrophic lateral sclerosis (ALS).

Analysis of her recent publications reveals a consistent focus on translational neuroscience, combining human neuronal models with proteomic and electrophysiological approaches. Her work identifies critical links between genetic mutations, synaptic dysfunction, and therapeutic responses, particularly in rare neurodevelopmental disorders and ALS subtypes.

Barbagallo operates within the Neuronal Signalling research group at the University of Copenhagen, collaborating extensively with international teams to map disease mechanisms and evaluate potential interventions for synaptic disorders.