معرفی
Pamela Bjorkman is the David Baltimore Professor of Biology and Biological Engineering and Merkin Institute Professor at the California Institute of Technology. She leads a research laboratory focused on structural immunology and virology, investigating immune responses against HIV-1, SARS-CoV-2, and other viral pathogens.
Her research interests center on immune recognition of viral pathogens, with particular focus on structural correlates of antibody-mediated neutralization. Using X-ray crystallography, electron microscopy, and biochemical approaches, her team studies pathogen glycoproteins and host immune proteins to develop improved therapeutics and vaccines. Key research areas include HIV-1, SARS-CoV-2, hepatitis C virus, and antibody engineering for increased potency and breadth.
Dr. Bjorkman has received numerous scientific honors including the 2025 Wolf Prize in Medicine and the 2021 Pearl Meister Greengard Prize. Her laboratory has made significant contributions to understanding viral immune recognition and developing novel antibody-based reagents.
She has mentored numerous students and postdoctoral researchers, many of whom have received prestigious awards including the Clauser Doctoral Prize. Her lab maintains active collaborations across structural biology and immunology research communities and contributes to important resources like the Variant Database for SARS-CoV-2 mutation analysis.
The Bjorkman Lab operates within Caltech's Division of Biology and Biological Engineering, utilizing advanced facilities including the Cryo-EM Facility and Molecular Observatory. Her research is supported by major grants including the HIVRADP01 project focused on developing immunogens to elicit broadly neutralizing anti-HIV-1 antibodies.
