معرفی
P. Murali Doraiswamy, MBBS, FRCP, is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine, Director of the Neurocognitive Disorders Program, Senior Fellow at the Duke Center for the Study of Aging and Human Development, and holds affiliate faculty appointments with the Duke Center for Applied Genomics & Precision Medicine, the Duke Microbiome Center, and the Duke Initiative for Science & Society. He is a Faculty Network Member of the Duke Institute for Brain Sciences and has advised major agencies including NIH, FDA, WHO, and the World Economic Forum.
Research Focus
Dr. Doraiswamy leads a multidisciplinary program that integrates advanced neuroimaging, multi-omics, digital therapeutics, and artificial intelligence to understand, predict, and prevent Alzheimer’s disease and related neurodegenerative disorders. His work spans:
- Development and validation of blood, CSF, imaging, and digital biomarkers for early detection and staging.
- Clinical trials of novel pharmacological, lifestyle, and digital interventions in mild cognitive impairment (MCI) and Alzheimer’s dementia.
- Systems-biology approaches combining genomics, metabolomics, lipidomics, and microbiome data to uncover mechanisms of resilience and risk.
- Policy translation and global mental health initiatives aimed at reducing disparities and improving brain health worldwide.
Publications & Impact
With more than 400 peer-reviewed publications and continuous federal and industry funding, his research has shaped current diagnostic algorithms and therapeutic pipelines. Recent work (2023-2025) demonstrates accelerated adoption of deep-learning MRI models for amyloid/tau staging, AI-guided companion robots to combat loneliness, and precision nutrition trials leveraging microbiome signatures.
Scientific Leadership & Recognition
He has chaired the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired innovation advisory councils for large social-impact funds. His findings have been featured by BBC, The New York Times, Scientific American, TIME, NPR, CBS Evening News, Oprah, The Dr Oz Show, and acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain.
Advocacy & Societal Engagement
Beyond the laboratory, Dr. Doraiswamy is a leading advocate for increased public and private investment in brain and behavioral research. He serves on multiple charitable boards and co-authored the popular book The Alzheimer’s Action Plan, translating cutting-edge science into practical guidance for patients and families.
