Osama A. Abulseoud

Osama A. Abulseoud, M.D., is a Professor and Interim Chair in the Department of Psychiatry & Psychology at Mayo Clinic in Phoenix, Arizona. He is a triple-board certified psychiatrist specializing in mood disorders, addiction psychiatry, and neuropsychiatric conditions associated with medical illnesses. His clinical expertise includes treatment-refractory depression, bipolar disorder, and the psychiatric management of patients undergoing neurostimulation such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS).

• Primary Appointment: Consultant, Department of Psychiatry & Psychology
• Academic Rank: Professor of Psychiatry
• Leadership Role: Interim Chair, Department of Psychiatry & Psychology
• Institution: Mayo Clinic, Phoenix, AZ

Dr. Abulseoud’s research focuses on the neurobiological mechanisms of psychiatric disorders, including bipolar disorder, substance use disorders, and post-COVID neuropsychiatric sequelae. He employs multimodal approaches such as human brain imaging, rodent behavioral models, molecular techniques, and single-cell transcriptomics to investigate glutamatergic dysregulation, ferroptosis, brain aging, and sex differences in addiction. A significant portion of his recent work explores melatonin as a ferroptosis inhibitor for mitigating post-COVID brain aging and neurodegeneration.

His 15 most recent publications reflect a strong trend toward translational neuroscience, with emphasis on molecular psychiatry, neuroprotection, and the intersection of systemic illness with mental health. Key themes include alcohol and cannabis effects on the brain, hyperglutamatergic states, DBS mechanisms, and perinatal addiction. His work integrates clinical observation with preclinical models to identify novel therapeutic targets.

Scientific awards and honors include:

• Director's Award for COVID Vaccine Efforts, NIH (2022)
• Distinguished Colleague, Teacher and Clinician, Mayo Clinic (2012)
• Best Grand Rounds Presentation, Mayo Graduate Program (2011)
• Best Teacher Award, University of Southern California (2008)

Dr. Abulseoud has been actively involved in research funding and mentorship, though specific grants and students are not listed. His editorial service as Academic Editor for PLOS One (2010–2021) highlights his contribution to scientific peer review. He leads a research program that bridges clinical psychiatry with neuroscience, contributing significantly to understanding and treating complex psychiatric conditions.