معرفی
Olle Kämpe is a Professor of Clinical Endocrinology at Karolinska Institutet, where he leads the Autoimmune Diseases Research Group within the Department of Medicine, Solna. His work focuses on understanding autoimmune mechanisms through the study of model diseases, particularly rare conditions like Addison's disease and APS-1. Kämpe's research has led to significant diagnostic advancements and potential new treatments for autoimmune conditions. He maintains strong collaborations with the Swedish Addison's Society and has established what is described as "the world's largest biobank for Addison's disease" with samples from over 1,000 patients.
Professor Kämpe's research interests center on understanding why the immune system attacks the body's own tissues, with particular focus on endocrine autoimmune disorders. His team employs a multidisciplinary approach spanning genetics, whole-genome sequencing, clinical studies, and registry research. A key discovery was identifying that the immune system in all Addison's disease patients reacts to the enzyme 21-hydroxylase, which is now used worldwide for diagnosis. His group investigates biological and genetic risk factors for autoimmune diseases, studies rare immunodeficiency conditions (APS1 and IPEX), and explores connections between autoimmune reactions and fertility issues. Notably, they've developed diagnostic markers that can identify women with Addison's disease at risk of premature infertility.
His recent publications demonstrate a strong focus on the intersection of autoimmunity, endocrinology, and genetics. Kämpe's work spans from basic immune mechanisms to clinical applications, with particular emphasis on Addison's disease, autoimmune polyendocrine syndromes, and sex differences in autoimmune conditions. His research increasingly incorporates advanced genomic techniques and large-scale population studies to identify genetic risk factors and develop better diagnostic tools.
- Wallenberg Clinical Scholar (2019)
- Extended Wallenberg Clinical Scholar grant (2025) for additional 5 years and 15 million SEK
- Project funding from Knut and Alice Wallenberg Foundation (2022)
Professor Kämpe has received substantial research funding that provides long-term stability for his work, which he notes is crucial for studying complex autoimmune conditions. His Wallenberg grant extension specifically supports research into self-limiting autoimmune conditions to understand physiological mechanisms that can interrupt attacks on the body's own tissue. He mentors doctoral students and postdoctoral fellows, with recent tutorial relationships including Anna Sjöström (Severe COVID-19 research) and Alice Costantini (rare metabolic bone diseases). His research group includes both clinical and basic science researchers working collaboratively across disciplines.
Kämpe's research group operates within Karolinska Institutet's Department of Medicine, Solna, maintaining close connections with clinical services to ensure research remains relevant to patient care. The group includes laboratory staff, clinical researchers, and computational biologists working together to advance understanding of autoimmune mechanisms. They maintain strong international collaborations, particularly with researchers in Bergen, Norway, and have developed specialized tools for studying autoimmune markers and genetic risk factors.
