معرفی
Odilia Corneth serves as a Researcher in the Department of Pulmonary Medicine at Erasmus University Medical Center's Faculty of Medicine, with an extensive publication record focused on immunological mechanisms in autoimmune diseases and sarcoidosis. Her work bridges clinical pulmonology and fundamental immunology research.
Her research spans B cell receptor signaling in autoimmune conditions like axial spondyloarthritis, autoantibody glycosylation patterns, and T cell dysregulation in sarcoidosis. Key interests include:
- Bruton tyrosine kinase pathways in B cells
- Memory B cell biology in autoimmunity
- PD-1+ T cell subsets as biomarkers
- Therapeutic response prediction in pulmonary diseases
Analysis of her recent publications reveals a strong focus on translational immunology, particularly how B and T cell signaling abnormalities correlate with clinical outcomes in autoimmune and inflammatory diseases. Her work increasingly integrates molecular profiling with clinical phenotyping to identify predictive biomarkers.
Dr. Corneth has supervised 3 doctoral candidates and collaborates extensively with the T2B consortium and international sarcoidosis research groups. Her current projects involve longitudinal monitoring of immune cell responses during B-cell depletion therapy and glucocorticoid treatment.
Her laboratory work centers on human immunophenotyping using flow cytometry and phospho-flow analysis of patient-derived immune cells, with emphasis on:
- Circulating double-negative B cells
- PD-1+ regulatory T cell subsets
- Autoantibody Fab region modifications
- Signaling molecule phosphorylation patterns
