معرفی
Nikos Tapinos is the Sidney A. Fox and Dorothea Doctors Fox Associate Professor of Ophthalmology, Visual Science, and Neuroscience at Brown University, affiliated with the School of Engineering and Department of Neurosurgery. He leads the Molecular Neuroscience & Neurooncology Lab, focusing on epigenetics, glial cell biology, and neuro-oncology.
- Research spans myelination mechanisms, glioma stem cell migration, RNA epigenetics, and novel therapies like GliaTrap hydrogels.
- Collaborations include departments of Pathology, Engineering, and Molecular Biology across Brown University.
Recent work emphasizes epigenetic regulation in glioblastoma using machine learning, enhancer RNAs, and HDAC inhibitors. Key technologies include enzyme-free tissue dissociation and electric field therapy platforms.
His lab investigates chromatin remodeling via antisense RNAs (e.g., Egr2 regulation) and mechanisms of glioma invasion in 3D models. Publications highlight integrative approaches to targeting glioma stem cells and Schwann cell biology.
