Nicolas CHARBONNEL

Nicolas CHARBONNEL is a permanent research staff member at the Laboratoire Microorganismes : Génome et Environnement (LMGE) at Université Clermont Auvergne, where he conducts research on bacterial pathogenesis, antibiotic resistance, and biofilm formation mechanisms. His work is primarily focused on Klebsiella pneumoniae and other pathogenic bacteria.

His research interests center around understanding the molecular mechanisms of biofilm formation and developing novel strategies to combat antibiotic-resistant bacteria. CHARBONNEL's work spans from fundamental studies of bacterial communication and gene regulation to applied research on antimicrobial compounds and CRISPR-Cas9 based resensitization approaches. He has made significant contributions to understanding how bacteria develop resistance within biofilm communities and how to overcome these defenses.

Analysis of his recent publications reveals a strong focus on developing novel antimicrobial compounds, particularly peptoid-based molecules that mimic natural antimicrobial peptides. His work also demonstrates increasing application of CRISPR-Cas9 technology to target antibiotic resistance genes directly within bacterial communities. A consistent theme across his research is the investigation of Klebsiella pneumoniae biofilm formation mechanisms and vulnerabilities.

CHARBONNEL collaborates extensively with Christiane Forestier and other researchers at LMGE, as well as with clinical researchers studying hospital-acquired infections. His research bridges fundamental microbiology with practical applications for combating antibiotic-resistant infections.