Nick Grishin

Nick Grishin is a Howard Hughes Medical Institute (HHMI) Investigator and Professor of Biochemistry at the University of Texas Southwestern Medical Center. His research focuses on understanding the evolutionary mechanisms of proteins and their structural-functional relationships.

Education:

• Diplom in Biochemistry from Moscow State University (Russia), equivalent to a Master's degree.
• Ph.D. in Molecular Biophysics at UT Southwestern Medical Center, mentored by Margaret Phillips.
• Postdoctoral training with Eugene Koonin at the National Institutes of Health (NIH).

Dr. Grishin’s work employs theoretical and computational approaches to analyze the expansion of protein diversity from ancestral forms. His lab develops methods to classify sequence-structure data, detect remote homologs, and integrate evolutionary considerations into protein analysis, enabling structure prediction and functional insights.

Scientific Awards:

• HHMI Investigator

At the Grishin Lab, he leads research on protein evolution, biological diversity, and computational biology. His team has created tools such as ECOD, MESSA, Promals3D, and ProCAIn to advance hierarchical classification and evolutionary analysis of proteins.