Nick Gay

Professor Nick Gay leads the Gay Research Group at the Department of Biochemistry, University of Cambridge. His work focuses on molecular mechanisms of Toll-like receptor (TLR) signaling, innate immune recognition of pathogens, and inflammatory disease regulation.

Research Interests:

• Structural and molecular analysis of TLR activation by microbial lipids and nucleic acids.
• Assembly of MyD88 and TRIF signaling scaffolds.
• Role of phosphoinositide metabolism in inflammation.
• Modulation of inflammatory signaling by Parkinson's disease-associated kinase LRRK2.
• Impact of innate immunity on chronic diseases like sepsis and American trypanosomiasis.

Methodology combines structural biology, biophysics, single-molecule imaging, and cell biology.