معرفی
Nanduri R. Prabhakar, Ph.D., D.Sc., is the Harold Hines Jr. Professor of Medicine at the University of Chicago, where he directs the Institute for Integrative Physiology and the Center for Systems Biology of Oxygen Sensing. His work bridges molecular mechanisms and whole-organism physiology, focusing on oxygen sensing, carotid body function, and the pathophysiology of intermittent hypoxia in conditions like sleep apnea.
Research interests span:
- Oxygen Sensing: Molecular pathways in carotid body chemoreceptors.
- Intermittent Hypoxia: Mechanisms linking sleep apnea to hypertension and metabolic dysfunction.
- Gasotransmitters: Roles of H₂S, CO, and NO in hypoxic signaling.
- Epigenetic Regulation: How hypoxia alters gene expression via histone modifications.
Publications emphasize hypoxia-inducible factors (HIFs), reactive oxygen species (ROS), and neural regulation of cardiorespiratory homeostasis, with recent work exploring therapeutic targeting of carotid body chemoreflexes.
Awards include:
- Michael de Burgh Daly Award (2016)
- Elected Fellow, American Physiological Society (2017)
- Julius H. Comroe Distinguished Lecture Award (2012)
Major NIH grants support projects on intermittent hypoxia consequences and carotid body therapeutics. He trains researchers through programs like the NIH T32 Training in Oxygen in Health and Disease.
