معرفی
Najib Rahman is Professor of Respiratory Medicine at the University of Oxford's Nuffield Department of Medicine, where he serves as Director of the Oxford Respiratory Trials Unit (ORTU) and Lead of the Oxford Pleural Translational Laboratory. He also holds key leadership positions as Deputy National Lead Respiratory Research for the NIHR Clinical Research Network and Co-Chair of the British Thoracic Society Pleural Guidelines Group.
- Director, Oxford Respiratory Trials Unit (ORTU)
- Lead, Oxford Pleural Translational Laboratory
- Deputy National Lead Respiratory Research, NIHR Clinical Research Network
- Thames Valley Clinical Research Network Respiratory Lead
- Co-Chair, British Thoracic Society Pleural Guidelines Group
Professor Rahman's research focuses on pleural diseases, particularly pleural infection, malignant pleural effusion, and pneumothorax. His work spans laboratory-based translational research, early-phase discovery science, and practice-changing clinical trials at both single and multi-center levels. His group has pioneered several major clinical trials that have changed international practice, including the MIST2 trial on pleural infection treatment and the TIME series of trials on malignant pleural effusion management.
Analysis of his recent publications reveals a continued focus on pleural disease diagnostics and management, with particular emphasis on ultrasound applications, proteomic analysis of pleural fluid, and comparative effectiveness of different interventions. His work bridges basic science, clinical trials methodology, and direct patient care applications.
- MIST2 trial (NEJM 2011) established a novel enzyme combination treatment for pleural infection
- RAPID score for predicting 3-month mortality in pleural infection (Chest 2014)
- TIME1, TIME2, TIME3 trials defining optimal management of malignant pleural effusion
- World's largest pneumothorax epidemiology study (JAMA 2019)
- Ongoing MIST3 trial comparing early thoracoscopic surgery to intrapleural fibrinolytic
Professor Rahman currently oversees a portfolio of over 50 studies through ORTU, including both academically led and industry-sponsored research. His work has established important biobanks of pleural fluid and blood samples, and his research has directly influenced clinical practice guidelines worldwide. He is actively involved in developing new diagnostic approaches and therapeutic strategies for pleural diseases, with a particular focus on personalized medicine approaches based on biological markers.
