Nagireddy Putluri

Nagireddy Putluri is a Professor at Baylor College of Medicine and Director of the Cancer Metabolomics Core. His research focuses on cancer metabolism, particularly bladder cancer, leveraging advanced mass spectrometry to study metabolic reprogramming. He holds a PhD in Analytical Chemistry from the Indian Institute of Chemical Technology and completed postdoctoral fellowships at the Pennington Biomedical Research Center and Medical College of Georgia.

Education:

• PhD in Analytical Chemistry (2007), Indian Institute of Chemical Technology
• MS in Organic Chemistry (2001), Osmania University
• BS in Chemistry (1998), Osmania University
• Postdoctoral Fellowships in Proteomics and Metabolomics (2007–2009)

Research interests include metabolic pathways in cancer development, racial disparities in bladder cancer, and translational biomarker discovery. His lab employs metabolomics, proteomics, and CRISPR-based tools to identify therapeutic targets, such as the IL6/JAK/STAT3 axis in SMARCB1-deficient bladder cancer.

Key findings include identifying xenobiotic metabolism alterations in African American bladder cancer patients and elucidating metabolic vulnerabilities like mitochondrial pyruvate import in prostate cancer. His work has been published in high-impact journals like Nature Communications, Science, and Cancer Research.

Grants include NIH/NCI funding for studies on racial disparities and bladder cancer metabolism, and Department of Defense support for risk-stratification using metabolomic signatures. The Cancer Metabolomics Core, led by Putluri, supports Texas Medical Center researchers with cutting-edge platforms for metabolomics and lipidomics.

Future directions focus on translating metabolomic insights into clinical applications, enhancing biomarker discovery, and addressing disparities in cancer outcomes.