معرفی
Nabab Khan is an Associate Research Scientist in the Department of Neuroscience at Yale School of Medicine, focusing on molecular mechanisms of viral pathogenesis and neurodegenerative disease. Their research explores endolysosomal regulation in SARS-CoV-2 and HIV-1 infection dynamics.
- Institutional Affiliation: Yale School of Medicine, Yale University
- Research Themes: Endolysosomal pH regulation, iron homeostasis, viral entry mechanisms, HIV-1 neurodegeneration
Current work investigates how endolysosomal iron release and pH modulation affect mitochondrial dysfunction and viral replication across multiple pathologies. Computational approaches like molecular dynamics simulations complement biochemical analyses.
Specific projects include:
- Regulation of SARS-CoV-2 entry via SLC38A9
- Aurora kinase A's role in amyloid β processing
- HIV-1 Tat protein's lysosomal escape mechanisms
- Therapeutic potential of dimethoxycurcumin in viral diseases
- Interactions between endolysosomal stress and neurodegenerative pathways
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