معرفی
NG Wirsdörfer is a research group leader at the University of Duisburg-Essen's Medical Faculty, specializing in Radiation Oncology and Immunomodulation. Their work focuses on radiation-induced immune changes in tumors and normal tissues, particularly lung toxicity mechanisms.
- University: University of Duisburg-Essen
- Radiation-related immunology and tumor resistance
- Grants: DFG, EU ITN THERADNET, Wegener Foundation
Research Themes: The group investigates how radiation therapy interacts with innate and adaptive immunity, identifying therapeutic targets to protect normal tissue while maintaining tumor control. They use co-clinical radiation models, multicolor flow cytometry, and advanced imaging to study NSCLC/HNSCC treatments.
Scientific Contributions: Key publications address biomarker development for pneumonitis/fibrosis, immune checkpoint inhibition combinations, and the role of CD39/CD73 and microbiome in radiation responses. 2023 articles in Neoplasia and J Immunother Cancer highlight overlapping immune-related adverse effects and glucocorticoid-mediated immunosuppression.
- Neuropilin-1 targeting in pulmonary fibrosis
- Pathological macrophage modulation
- Microbiome effects in radioimmunotherapy
Team Leadership: Supervises doctoral students Irene Bocci, Alexander Ziebolz, and Hugo Laporte. Collaborates with Prof. Verena Jendrossek and PD Dr. Nika Guberina on projects funded by GRK2762/1 and the UMESciA initiative.
