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معرفی
N. Sadananda Singh is an Assistant Professor Grade I in the School of Biology at Indian Institute of Science Education and Research Thiruvananthapuram. His research focuses on genetic factors and mechanisms behind biological systems and responses to external agents, particularly cytotoxic drugs and lipid metabolism disorders.
His educational background includes:
- Ph.D. (2007) in Microbiology and Cell Biology from Indian Institute of Science, Bangalore, under Prof. Umesh Varshney
- M.Sc. (Biotechnology) from University of Hyderabad
- B.Sc. (Chemistry Honors) from Hans Raj College, University of Delhi
Singh's research program investigates genetic factors responsible for drug responses using genome editing technologies. His laboratory specializes in CRISPR-Cas applications for identifying genetic modifiers of drug response, with particular emphasis on cytotoxic drugs. Additional research focuses on molecular genetic analysis of lipid disorders, especially cholesterol metabolism, aiming to distinguish genetic from environmental factors in disease manifestation. His work bridges fundamental molecular mechanisms with potential clinical applications in personalized medicine.
His publication record shows an evolution from bacterial translation mechanisms to human cell-based genetic studies. Early work (2005-2010) focused on ribosome recycling and cell division in bacterial and yeast systems, while more recent publications (2011-2016) demonstrate a shift toward translational research involving human cell models, lipid metabolism, and genome editing technologies for disease modeling.
His scientific achievements include:
- Travel Grant from Asia Pacific Federation of International Atherosclerosis Society
- Best poster award at SAB meet 2011, Temasek LifeSciences Laboratory
- Junior and Senior Research Fellow of CSIR
- SPM fellowship recipient (top 20% in CSIR JRF)
- Scholarship from Department of Biotechnology, India
Singh has substantial research experience from his positions as Research Fellow at Temasek Lifesciences Laboratory, Singapore (2007-2013) and Translational Laboratory in Genetic Medicine, BMSI, A-STAR, Singapore (2013-2016). His work has been supported by competitive fellowships throughout his career, including CSIR funding and Department of Biotechnology support during his graduate studies.
His laboratory at IISER Thiruvananthapuram applies genome editing technologies to investigate genetic factors involved in drug response and lipid disorders using human cell lines as model systems for gene function studies through disruption, deletion, or induction of specific genes and genomic regions.
