Mårten Fryknäs

Mårten Fryknäs is a Senior Lecturer at the Department of Medical Sciences, Uppsala University, specializing in Cancer Pharmacology and Computational Medicine. His research bridges drug discovery, tumor biology, and computational approaches to improve cancer therapies.

His work focuses on

• Drug repositioning for hematological and solid tumors
• 3D tumor spheroid models for drug testing
• Proteasome and mitochondrial targeting in cancer cells
• Epigenetic and microenvironmental factors in drug resistance

Recent publications highlight

• Immuno-oncology assays
• Extracellular matrix effects on hepatocellular carcinoma
• Statins as immune enhancers
• Mechanistic studies of mebendazole and nitazoxanide

across journals like Scientific Reports and Nature Communications.

His laboratory employs advanced techniques such as

• Automated label-free video microscopy
• High-throughput screening
• Proximity ligation assays
• Gene expression profiling

to identify novel cancer therapeutics and understand drug activity in context-dependent models.