Monika Leischner-Brill

Monika Leischner-Brill is a research group leader at the Institute of Neuronal Cell Biology within the School of Medicine at the Technical University of Munich (TUM). She holds the academic rank of Associate Professor and is a full member of the Graduate School of Systemic Neurosciences (GSN), reflecting her senior position in academic neurosciences.

Her research centers on neuronal cell biology with a focus on microtubule cytoskeleton dynamics in motor neurons. She investigates posttranslational modifications and cytoskeletal alterations during development and in motor neuron diseases like ALS. Her laboratory employs quantitative immunostainings, electron microscopy, and live imaging of transgenic/virally injected mice to study axonal homeostasis, neuromuscular junction formation, and degeneration mechanisms. Keywords defining her work include axon biology, cytoskeleton, and microtubule modifications.

Analysis of her publication history reveals consistent thematic progression from developmental neuroscience (e.g., adult neurogenesis in olfactory systems) toward disease mechanisms, with increasing emphasis on motor neuron pathology and cytoskeletal dynamics. Recent work integrates viral vector techniques with high-resolution imaging to dissect spatiotemporal aspects of axonal remodeling and glial interactions.

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Laboratory and Team: Dr. Leischner-Brill leads an independent research group at TUM's Institute of Neuronal Cell Biology, utilizing advanced microscopy and genetic models to explore fundamental mechanisms of neuronal structure and function with translational implications for neurodegenerative disorders.