معرفی
Monica E. Neugebauer is an Assistant Professor in the Department of Biochemistry at the University of Wisconsin–Madison and holds an affiliate appointment in the Department of Chemistry. She leads a multidisciplinary research group focused on discovering and evolving enzymes—especially metalloenzymes—for applications in biocatalysis and chemical biology.
Education
- B.S., Massachusetts Institute of Technology
- Ph.D., University of California, Berkeley
- Postdoctoral Fellow, Broad Institute of MIT and Harvard
Research Interests
The Neugebauer laboratory integrates biochemistry, structural biology, protein engineering, and directed evolution to uncover and optimize enzymes capable of performing challenging chemical transformations. A major focus is on metalloenzymes that carry out C–H functionalization and halogenation reactions using earth-abundant metals. By solving high-resolution enzyme structures and applying phage-assisted continuous evolution, the group aims both to create practical biocatalytic tools and to elucidate fundamental principles of enzyme selectivity.
Publication Trends
Across her 2019–2024 portfolio, Dr. Neugebauer has published extensively on genome-editing technologies (base editors, prime editors) and on radical enzymology (halogenases, diiron oxidases). The work spans from Nature Biotechnology and Cell to specialized journals such as Biochemistry and Nature Chemical Biology, showcasing a trajectory from mechanistic enzymology to translational biotechnology.
Scientific Awards
No specific awards are mentioned in the provided text.
Training & Mentorship
The lab currently trains six graduate students and one undergraduate researcher across the Integrated Program in Biochemistry (IPiB), Chemistry, Biophysics, and the combined DVM/PhD program. Rotation students and prospective graduate students are encouraged to contact Dr. Neugebauer directly.
Laboratory & Facilities
The group operates from 341B HF DeLuca Biochemistry Laboratories at 433 Babcock Drive, Madison, WI. Shared departmental facilities provide access to mass spectrometry, NMR spectroscopy, X-ray crystallography, and high-throughput screening capabilities, fostering a collaborative and resource-rich environment.
