Mona Al Mukaddam

Mona Al Mukaddam is a Clinical Professor of Medicine at the Perelman School of Medicine, University of Pennsylvania. She serves as a leading endocrinologist specializing in rare bone diseases, particularly Fibrodysplasia Ossificans Progressiva (FOP) and hypophosphatasia, while maintaining expertise in metabolic bone and calcium disorders such as osteoporosis and parathyroid pathologies.

• Education
  • BS in Biological Sciences, American University of Beirut (2001)
  • MD, American University of Beirut (2005)
  • MS in Translational Medicine, University of Pennsylvania (2013)

Her clinical work focuses on diagnosing and treating rare bone diseases, including FOP, hypophosphatasia, and transplant-related bone conditions. Research efforts leverage ultrahigh-resolution MRI (uMRI) to study bone quality in metabolic disorders. She actively contributes to global FOP guidelines through the International Clinical Council on FOP and collaborates on drug trials like the MOVE and PIVOINE studies.

Recent publications emphasize FOP treatment optimization, machine learning in fracture risk prediction, and drug safety profiles. Notable activities include FDA advisory work on palovarotene - the first disease-modifying therapy for FOP, and patient education initiatives through the Penn Bone Center and Penn Primary Care Podcast.