معرفی
Mohamed Farah is an Associate Professor in the Department of Neurology at the Johns Hopkins University School of Medicine. His research focuses on the cellular and molecular mechanisms of axonal regeneration and neurodegeneration, particularly in peripheral nerve injury and motor neuron diseases such as ALS.
His primary research areas include:
- Cellular and Molecular Neuroscience
- Neurobiology of Disease
- Axonal Regeneration in the Peripheral Nervous System
- Motor Neuron Disease Models
- Human iPSC-Derived Neuron Pathobiology
Dr. Farah's recent publications highlight his work on enhancing axonal regeneration through BACE1 inhibition, modeling ALS using patient-derived iPSCs, and developing microfluidic platforms for live imaging of neuronal regeneration. His studies integrate rodent models of peripheral nerve injury and neuropathy with advanced in vitro 3D neuronal spheroid cultures to investigate therapeutic strategies for accelerating nerve repair and counteracting neurodegeneration.
His research has been published in high-impact journals such as Scientific Reports and Annals of Clinical and Translational Neurology, demonstrating a strong focus on translational neuroscience and preclinical therapeutic development.
Dr. Farah leads an active research laboratory that employs morphological, electrophysiological, and behavioral methodologies. His lab has secured research funding (implied by ongoing projects) and collaborates with experts in neurology and translational neuroscience. He mentors junior researchers and students, contributing to training the next generation of neuroscientists.
His lab is particularly known for its work on:
- The LTN/CMM system for studying axonal sprouting in ALS models
- RNA profiling of axons and somas in ALS patient-derived motor neurons
- Pharmacological and genetic manipulation of BACE1 and its substrates (APP, TNFR1)
