معرفی
Misrahi Micheline is a Professor Exceptional Class at the University Paris Saclay, leading the Genetics of Metabolic and Reproductive Diseases Unit at Bicêtre Hospital. She serves as a National Referent for Genetic Infertility and Primary Ovarian Insufficiency (POI) under the French Ministry of Health. Her roles include heading research units focused on reproductive and metabolic diseases, and she has held directorships in INSERM (French NIH) and university research programs.
Education: She earned her PhD in Biochemistry and Molecular Biology from Paris VI (1989) and a medical degree from Paris V (1985). Her research focuses on sex steroid receptors, thyroid endocrinology, and genetic defects underlying infertility and POI. She pioneered studies on the human progesterone receptor and TSH receptor, contributing foundational knowledge in reproductive endocrinology.
Research Interests: Her work spans molecular genetics of reproductive disorders, personalized medicine, and translational applications of genetic findings. Key areas include identifying genetic causes of POI and infertility, with emphasis on receptor dysfunction and therapeutic targets. She leads international collaborations, such as a European Network on POI (9 countries).
Publications: Her work highlights genetic insights into POI, BRCA2’s role in fertility, and LH receptor mutations. These studies emphasize personalized medicine and genetic counseling implications. Recent trends focus on NGS applications in clinical practice and cancer-risk correlations in genetic infertility.
- Awards: Elected to European Academy of Sciences (2022), Jean Marie Lehn Prize (2022), INSERM Scientific Council Member (2008–2012), and multiple doctoral supervision awards.
- Leadership: Editor-in-Chief of International Journal of Molecular Science (2018–2021), Head of ESHRE POI Guideline Group (2022), and advisory roles at global institutions like the Virtual Academy of Genetics.
Labs & Teams: Leads the Molecular Genetics Unit at Bicêtre Hospital and coordinates a multidisciplinary European initiative on POI. Her lab integrates clinical genetics, endocrinology, and bioinformatics to advance fertility treatments and diagnostic strategies.
