معرفی
Dr. Ming Li is a Lecturer in Clinical Neurobiology at the University of Plymouth, affiliated with the Peninsula Medical School within the Faculty of Health. His research focuses on glioblastoma (GBM) tumor microenvironment (TME), immune evasion mechanisms, and developing novel therapeutic strategies. Dr. Li completed a PhD in Molecular Biology at the University of Hong Kong and postdoctoral training at the Ludwig Institute for Cancer Research, UC San Diego. Previously, he served as an Assistant Professor in Neurosurgery at the University of Minnesota. His work integrates cutting-edge techniques including CRISPR/Cas9, spatial transcriptomics, and single-cell RNA sequencing to study GBM immunosuppression and therapeutic resistance.
Research interests include understanding how innate immunity-associated genes like GBP proteins drive GBM malignancy, and exploring pharmacological interventions (e.g., PI3Kγ inhibitors) to reprogram the TME. Key projects involve combining immune checkpoint inhibitors with genetic/pharmacological approaches to enhance anti-tumor immunity. This work contributes to SDGs addressing health and innovation.
Publications highlight discoveries in GBM signaling pathways (GBP3/5, FHL2, EGFRvIII), microglia/macrophage roles in TME, and drug resistance mechanisms. Ongoing studies aim to translate findings into clinical therapies.
