Mikhail Shapiro

Mikhail Shapiro is the Max Delbrück Professor of Chemical Engineering and Medical Engineering at the California Institute of Technology, and an Howard Hughes Medical Institute Investigator since 2021. His research laboratory develops acoustic and magnetic biomolecular tools for imaging and controlling cellular function in vivo.

• Chemical Engineering Faculty
• Medical Engineering Affiliation
• Howard Hughes Medical Institute Investigator

Research focuses on noninvasive control of biological systems through:

• Acoustic reporter genes (ARG 2.0) for real-time tumor monitoring
• Ultrasound neuroimaging via acoustically transparent cranial windows
• Gas vesicle engineering for cellular manipulation
• Microrobotics with acoustic hydrogels

His 2024-2025 publications demonstrate breakthroughs in:

• Nonlinear ultrasound for deep-tissue visualization
• Acoustic percolation switches for targeted drug delivery
• SEMPER systems for multi-gene expression control

Scientific recognition includes:

• HHMI Investigator (2021-)
• Vilcek Foundation Prize in Biomedical Innovation
• Roger Tsien Award for Chemical Biology
• Packard Fellowship in Science and Engineering