Michele Guescini

Michele Guescini serves as an Associate Professor in the Department of Biomolecular Sciences at the University of Urbino Carlo Bo. His academic profile indicates active engagement in both teaching and research, with courses spanning Biochemistry, Molecular Biology of Exercise, and Extracellular Vesicles. His institutional affiliation places him within the Italian academic system, contributing to programs in Sports Science, Health, and Preventive Motor Activities.

Dr. Guescini's research interests center on extracellular vesicles (EVs) and their multifaceted roles in physiological and pathological processes. His work explores how physical exercise influences EV release and function, particularly in muscle adaptation and inflammatory responses. Additional research areas include the relationship between caveolin-1 expression and EV secretion in cancer models (specifically rhabdomyosarcoma), EV-based biomarkers for neurological conditions like Alzheimer's disease, and the therapeutic potential of EVs in drug delivery systems. His research demonstrates a strong interdisciplinary approach bridging biochemistry, molecular biology, exercise physiology, and clinical applications.

Analysis of his recent publications reveals a consistent focus on extracellular vesicle biology, with particular emphasis on their role as mediators of intercellular communication in exercise physiology, cancer biology, and neurodegenerative disorders. His work often examines how EV cargo (particularly proteins and miRNAs) changes under different physiological conditions and how these changes influence cellular responses. The research demonstrates both basic science investigations into EV biogenesis and more applied studies exploring EVs as diagnostic biomarkers and therapeutic vehicles.