معرفی
Michael Wong serves as the Allen P. and Josephine B. Green Professor of Pediatric Neurology in the Department of Neurology at Washington University School of Medicine. His research laboratory investigates cellular and molecular mechanisms underlying epilepsy to develop novel therapeutic interventions for patients.
His primary research focuses on epileptogenesis and seizure-induced brain injury using pharmacological and genetic animal models. Key methodologies include electrophysiology (patch-clamping, in vivo video-EEG), histological assays, molecular biology techniques, and advanced cellular imaging (confocal/two-photon microscopy). Major contributions involve Tuberous Sclerosis Complex (TSC) research, demonstrating mTOR pathway inhibition prevents epilepsy development in mouse models and exploring dendritic damage mechanisms underlying cognitive deficits.
Dr. Wong co-leads research at the WashU Medicine Tuberous Sclerosis Center, integrating basic science with clinical trials. Recent work includes investigating sleep aids like lemborexant for neurodegenerative disorders (e.g., Alzheimer's disease) and developing actin-stabilizing therapies to mitigate seizure-induced neuronal damage. Ongoing studies target novel therapeutic pathways for acquired epilepsy and neurological consequences of seizures.
