Michael Oldham

Dr. Michael Oldham is an Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF) School of Medicine. He serves as Principal Investigator for multiple NIH R01 grants focusing on adult malignant gliomas, tumor vasculature, and human brain evolution. His lab develops computational resources like OMICON and CTEC for analyzing human brain transcriptomes.

• University: UCSF
• Department: Neurological Surgery
• NIH Grants: R01CA292649, R01MH123156, R01CA244621, R01MH113896

Dr. Oldham’s research integrates gene coexpression analysis, computational biology, and experimental strategies to study cellular identity in health and disease. His work spans neuro-oncology, developmental neuroscience, and metascience, with a focus on reproducibility in large-scale data analysis.

Recent publications highlight his expertise in glioma heterogeneity, prenatal neurovascular development, and human-specific gene regulatory mechanisms. He actively contributes to PhD programs in Neuroscience, Biomedical Sciences, and Biomedical Informatics at UCSF.

• 2025: Cortical organoids and METTL5 regulation
• 2024: Tumor immunosuppressive programs and 3D glioblastoma evolution
• 2023: Egfr deletions in gliogenesis and microRNA melanoma diagnostics

Scientific Awards:

• Weill Institute Scholar Award (2016)
• Early Stage Investigator Award (NIH R01, 2017)
• Eva Kavan Prize (2008)
• BREAKTHROUGH BIOMEDICAL RESEARCH AWARD (2015)

Dr. Oldham’s lab is located in the Helen Diller Family Cancer Research Building at UCSF Mission Bay, with affiliations to the Brain Tumor Center, Weill Institute for Neurosciences, and Eli and Edythe Broad Center of Regeneration Medicine.