Joseph Costello

Joseph Costello is a Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF), School of Medicine. He is affiliated with the UCSF Weill Institute for Neurosciences and the UCSF Cancer Center.

His research focuses on genomics, epigenomics, and cancer biology, with an emphasis on brain tumors like glioblastoma and glioma. He leads projects on tumor heterogeneity, molecular evolution, and therapeutic target discovery. Key areas include:

• Genomic effectors of immunosuppression in malignant transformation
• Placental epigenome dynamics in preeclampsia
• Molecularly targeted vaccines for glioma

Recent publications (2023–2025) demonstrate trends in spatial 3D genome analysis, RNA splicing aberrations, longitudinal tumor profiling, and neural engineering applications. His work consistently integrates multiomic approaches to address intratumoral heterogeneity and therapy resistance.

He currently leads active NIH grants including:

• R01CA244838: 3-D spatial approach to discover genomic effectors of immunosuppression during malignant transformation (2020–2025)
• T32CA151022: Training Program in Translational Brain Tumor Research (2010–2025)

No scientific awards or student advisees are listed in the source material. His lab collaborates within the UCSF Weill Institute for Neurosciences on brain tumor research initiatives.