معرفی
Michael Gregory Fried, PhD, is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, within the College of Arts and Sciences. His research is centered on the biophysical mechanisms of macromolecular assembly, particularly protein-DNA and protein-protein interactions.
- University: University of Kentucky
- School: College of Arts and Sciences
- Department: Department of Molecular and Cellular Biochemistry
- Position: Professor
Education:
- A.B. in Biology, Dartmouth College, 1976
- Ph.D. in Molecular Biophysics, Yale University, 1982
- Postdoctoral Training in Biochemistry, University of Minnesota, 1982–1985
Dr. Fried's research investigates how proteins interact with DNA, with a focus on the DNA-repair protein O⁶-alkylguanine-DNA alkyltransferase (AGT), which plays a critical role in protecting genomic integrity and contributes to tumor resistance in chemotherapy. His work combines biophysical and biochemical techniques to understand binding kinetics, cooperativity, and structural changes in macromolecular complexes.
His recent publications (up to 2024) demonstrate a sustained focus on cooperative binding, DNA repair mechanisms, and the development of analytical methods such as EMSA and ultracentrifugation. These studies span disciplines including biochemistry, molecular biology, and biophysics, with subfields ranging from chromatin regulation to enzyme kinetics and nucleic acid recognition.
While no scientific awards are listed in the provided text, Dr. Fried has contributed significantly to methodological literature and mechanistic studies in DNA repair. His advising and grant activities are not detailed, but his long-standing research program suggests active mentorship and funding support. He has no listed students in the provided data. His lab likely operates within the broader research ecosystem of the Department of Molecular and Cellular Biochemistry, focusing on experimental biophysics of nucleic acid interactions.
