Michael Giacomelli

Michael Giacomelli is a Professor specializing in biomedical imaging technologies. He previously worked as a research scientist at MIT's Research Lab of Electronics, collaborating with Beth Israel Deaconess Medical Center and the VA Medical Center in Boston. His research focuses on multiphoton and fluorescence imaging for clinical and surgical applications, emphasizing real-time pathology assessment. He holds a PhD in Biomedical Engineering from Duke University and dual B.S. degrees in Computer Engineering and Computer Science from the University of Arizona.

Research interests include multiphoton microscopy, high-throughput imaging systems, and medical imaging instrumentation. The Giacomelli Lab designs custom microscopes and algorithms for clinical use, prioritizing usability by non-engineers. Recent work emphasizes silicon photomultiplier arrays and piston-based specimen holders to improve imaging speed and accuracy in surgical settings.

Key advancements include real-time margin assessment during Mohs surgery and rapid biopsy analysis. His innovations bridge engineering and medicine, with applications in oncology, dermatology, and gastroenterology. The lab collaborates extensively with clinical partners to translate technologies into usable diagnostic tools.

Publications from 2024-2025 highlight improvements in imaging speed, spectral throughput, and clinical validation of imaging systems. Current work focuses on low-cost solutions for tissue processing and enhancing detector sensitivity for wide-scale clinical adoption.