معرفی
Melike Sapmaz METİN serves as an Associate Professor at Trakya University Faculty of Medicine, Department of Histology and Embryology since 2018, following progressive academic appointments including Assistant Professor positions at the same institution since 2014. Her career spans over two decades of research in reproductive biology and toxicology.
Educational background:
- Doctoral Degree (2008): Histology and Embryology, Trakya University (Thesis: Effects of Ionizing Radiation on Ovarian Morphology)
- Master's Degree (2004): Trakya University
- Bachelor's Degree (2000): Trakya University
Her research focuses on reproductive toxicology, particularly investigating ovarian and uterine responses to environmental toxins (cadmium, phthalates, radiation), stress-induced reproductive damage, and protective mechanisms of natural compounds like curcumin and quercetin. Current work examines molecular pathways involving JNK, TGF-β1, and inflammatory mediators in conditions ranging from colitis to diabetic testicular dysfunction. Her methodology integrates histopathological analysis with molecular techniques to assess apoptosis, oxidative stress, and hormonal regulation.
Analysis of her 15 most recent publications reveals dominant research themes: 60% focus on renal and gastrointestinal pathologies (particularly cisplatin-induced nephrotoxicity and colitis), 30% on reproductive toxicology (ovarian/uterine damage from toxins/stress), and 10% on burn wound models. Key molecular targets consistently include JNK, TGF-β1, NF-κB, and oxidative stress markers, with natural compounds serving as primary therapeutic interventions.
She actively supervises graduate research, currently advising a Master's thesis on chronic stress effects on ovarian follicular development. Her funded projects include TÜBİTAK and university-supported studies on phthalate toxicity, titanium dioxide nanoparticle effects, and ischemic conditioning therapies.
