Megan Laura McCain

Megan Laura McCain is a Professor of Biomedical Engineering at the University of Southern California (USC), with a secondary appointment in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine. She leads the McCain Lab, focused on developing microphysiological systems, particularly heart- and muscle-on-a-chip models, to study disease mechanisms and therapeutic responses. McCain holds affiliations with the Biomedical Engineering Society, American Society for Cell Biology, and American Heart Association.

Her education includes a B.S. in Biomedical Engineering from Washington University in St. Louis (2006), a Ph.D. in Engineering and Applied Sciences from Harvard University (2012), and postdoctoral research at Harvard’s Wyss Institute. Notable awards include the American Heart Association Pre-doctoral Fellowship and Harvard’s Derek Bok Certificate of Distinction in Teaching.

McCain’s research integrates tissue engineering, stem cell biology, and microfluidics to model complex biological systems. Her work emphasizes understanding how microenvironments influence cellular behavior in diseases like cardiovascular disorders and muscular dystrophy. Recent studies explore paracrine interactions in engineered tissues, sex-based proteomic differences in vascular cells, and hypoxia-induced signaling in cardiac fibroblasts.

Her scientific contributions include advancements in 3D bioprinting, microfluidic platforms for disease modeling, and synthetic biology tools for cellular control. McCain’s lab collaborates widely to translate findings into clinical applications, such as personalized medicine and regenerative therapies.